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Living organisms are programmed to perform multiple functions by sensing intra‐ and extra‐cellular environments and by controlling gene expressions. Synthetic biologists aim to program cells by mimicking, designing, and constructing… Click to show full abstract
Living organisms are programmed to perform multiple functions by sensing intra‐ and extra‐cellular environments and by controlling gene expressions. Synthetic biologists aim to program cells by mimicking, designing, and constructing genetic circuits. Synthetic mRNA‐based genetic switches and circuits have attracted attention for future therapeutic applications because of their safety and functional diversity. Here, the mRNA‐based switches and circuits that detect specific microRNAs or proteins expressed in a target cell to control transgene expression and cell fate are reviewed. Future perspectives of artificial RNA systems for cell engineering will also be addressed.
Journal Title: Advanced Biosystems
Year Published: 2020
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