LAUSR

ZIF‐8 ranks among the most important metal‐organic frameworks and is widely utilized in various biomedical applications. In bone tissue reconstruction, ZIF‐8 is utilized for generating bone frameworks owing to its unique properties. Its proper porosity supports nutrient circulation and waste elimination, while its pore dimensions can be adjusted for specific applications. ZIF‐8 is thermally and chemically stable, resistant to moisture, and exhibits low cellular toxicity, making it suitable for implantation. As a porous material, ZIF‐8 enhances the osteogenic differentiation of mesenchymal stem cells, thereby accelerating bone formation and maturation. Its gradual degradation releases zinc ions, which aid in bone healing. ZIF‐8 can be used as a framework material for bone restoration, acting as a template for the accumulation of calcium phosphate minerals. The extensive surface area and adjustable pore size of ZIF‐8 facilitate the efficient loading and discharge of bioactive molecules, promoting bone healing. The unique combination of properties of ZIF‐8 makes it a promising candidate for constructing bone scaffolds with enhanced regenerative capabilities.