LAUSR

Drug release devices of small molecules are widely used in cell stimulation, drug delivery, and microenvironment regulation. Herein, a flexible drug release device (FDRD) powered by a triboelectric nanogenerator (TENG) is demonstrated, that has the superiority of low power consumption, flexible structure, and controllable release. In the self‐powered FDRD, the TENG can effectively harvest and transfer biomechanical energy into electricity. With a power management module, the TENG can provide a steady voltage supply for sustainable drug release, and the unique switchable wettability of poly(3‐hexylthiophene) films in Na2SO4 aqueous solutions can be regulated. The UV–vis absorption spectra of small molecules including methylene blue, fluorescein sodium, and rhodamine 6G released from the FDRD can be observed and recorded in real time. Furthermore, the releasing rate of conventional salicylic acid with the effect of removing cutin, sterilizing, and diminishing inflammation is also recorded in Na2SO4 aqueous solution. With the advantages of flexible structure, and controllable and sustainable release, the self‐powered FDRD is expected to find great potential in wearable medical devices, drug controllable release, and self‐powered therapy.