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Lung‐Targeted Rnai Therapeutics: Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer (Adv. Funct. Mater. 18/2019)

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advanced materials that can achieve specific cellular targeting together with efficient intracellular trafficking for reaching target sites in the cytosol. In article number 1807677, Ikramy A. Khalil, Hideyoshi Harashima, and… Click to show full abstract

advanced materials that can achieve specific cellular targeting together with efficient intracellular trafficking for reaching target sites in the cytosol. In article number 1807677, Ikramy A. Khalil, Hideyoshi Harashima, and co-workers use nanoparticles modified with the GALA peptide as targeted therapy for the lung endothelium, resulting in a robust gene knockdown. The nanoparticles are successfully applied for the regression of metastatic lung cancer. LUNG-TARGETED RNAi THERAPEUTICS

Keywords: lung; metastatic lung; lung endothelium; robust gene; regression metastatic; gala peptide

Journal Title: Advanced Functional Materials
Year Published: 2019

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