LAUSR

Minimally invasive manipulation of cell signaling is critical in basic neuroscience research and in developing therapies for neurological disorders. Here, a wireless chemomagnetic neuromodulation platform for the on‐demand control of primary striatal neurons that relies on nanoscale heating events is described. Iron oxide magnetic nanoparticles (MNPs) are functionally coated with thermoresponsive poly (oligo (ethylene glycol) methyl ether methacrylate) (POEGMA) brushes loaded with dopamine. Dopamine loaded MNPs‐POEGMA are co‐cultured with primary striatal neurons. When alternating magnetic fields (AMF) are applied, MNPs undergo hysteresis power loss and dissipate heat. The local heat produced by MNPs initiates a thermodynamic phase transition on POEGMA brushes resulting in polymer collapse and dopamine release. AMF‐triggered dopamine release enhances the response of dopamine ion channels expressed on the cell membranes enhancing the activity ≈50% of striatal neurons subjected to the treatment. Chemomagnetic actuation on dopamine receptors is confirmed by blocking D1 and D2 receptors. The reversible thermodynamic phase transition of POEGMA brushes allow the on‐demand release of dopamine in multiple microdoses. AMF‐triggered dopamine release from MNPs‐POEGMA causes neither cell cytotoxicity nor promotes cell reactive oxygen species production. This research represents a fundamental step forward for the chemomagnetic control of neural activity using hybrid magnetic nanomaterials with tailored physical properties.