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Full-Thickness Heart Repair with an Engineered Multilayered Myocardial Patch in Rat Model.

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In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular… Click to show full abstract

In a rat model of right free wall replacement, the transplantation of an engineered multilayered myocardial patch fabricated from a polycaprolactone membrane supporting a chitosan/heart matrix hydrogel induces significant muscular and vascular remodeling and results in a significantly higher right ventricular ejection fraction compared to use of a commercially available pericardium patch.

Keywords: patch; myocardial patch; multilayered myocardial; engineered multilayered; rat model

Journal Title: Advanced healthcare materials
Year Published: 2017

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