LAUSR

The inhibition of inflammation and the promotion of early angiogenesis have been paid much attention in skin tissue engineering. Citric acid-based biomaterials are widely used in tissue engineering due to their bioactive structure and biocompatibility, but there are few studies on investigating their role and mechanism in wound repair and skin regeneration. Herein, we report the potential anti-inflammation mechanism of poly(octanediol-citrate-polyglycol) (POCG) copolymer in regulating skin wound repair. It was found that POCG could modulate macrophages phenotype through downregulating the expression of pro-inflammatory cytokines (Tnf-α, IL-1β and IL-6) and polarizing macrophages to anti-inflammatory (M2) phenotype. POCG could promote endothelial cell vascularization by increasing the expression of angiogenesis factors (Vegf and CD31) mediated by the macrophage polarization. The in vivo study showed that POCG could accelerate skin wound repair through suppressing the acute inflammation and inducing early angiogenesis through the polarization modulation. Furtherly, the POCG polymer has good biocompatibility for both immune cells and tissue cells. This study may provide the important theoretical support on the bioactivity of citrate-based biomaterials and expanding their applications in tissue engineering. This article is protected by copyright. All rights reserved.