LAUSR

The treatment of severe burn injuries is a crucial challenge in skin tissue engineering. Severe burns always accompany with large-area neurovascular networks damaged, leading to the lack of excitation functions and difficulty in self-healing. Therefore, it is of great importance to develop the biomaterials, which could not only promote wound healing but also simultaneously reconstruct cutaneous neurovascular networks. In this study, Zn2 SiO4 (ZS) nanoparticles incorporated bioactive nanofibrous scaffolds were designed for innervated and vascularized skin burn wound healing. ZS nanoparticles with spindle-like morphology were synthesized via a facile hydrothermal method. The incorporation of ZS nanoparticles endowed the scaffolds with excellent angiogenic and neurogenic activities in vitro. Additionally, the In Vivo results showed that the ZS nanoparticles-incorporated scaffolds had favorable re-epithelialization, innervation and vascularization abilities through locally release of bioactive Zn and Si ions from ZS nanoparticles, leading to the rapid wound healing featured with newly formed blood vessels and nerve fibers. Taken together, our study suggests that the spindle-like ZS nanoparticles are useful bioactive agents for stimulating vascularization and innervation of functional skin repair. The bioactive inorganic nanoparticles may be used for multifunctional tissue regeneration. This article is protected by copyright. All rights reserved.