LAUSR

Cancer immunotherapy is revolutionary in oncology and hematology. However, a low response rate restricts the clinical benefits of this therapy owing to inadequate T lymphocyte infiltration and low delivery efficiency of immunotherapeutic drugs. Herein, an intelligent nano-vehicle (F/IMO@CuS) armed with multi-functional navigation is designed for the accurate delivery of cargoes to tumor cells and dendritic cells (DCs), respectively. The nano-vehicle is based on a near infrared-responsive inorganic CuS nanoparticles, acted as a photosensitizer and carrier of the chemotherapeutic agent oxaliplatin, and entered tumor cells owing to the presence of folic acid on the surface of CuS upon intratumoral injection. Furthermore, a Toll-like receptor (TLR) 7/8 agonist-conjugated polymer, anchored on the surface of CuS, is modified with mannose to bind with DCs in the tumor microenvironment. Upon exposure to laser irradiation, nano-vehicles disassembled, releasing oxaliplatin, to ablate tumor cells and amplify immunogenic cell death in combination with photothermal therapy. Mannose-modified polymer-TLR7/8 agonist conjugates are subsequently exposed, leading to the activation of DCs and proliferation of T cells. Collectively, these intelligent nano-vehicles reduce tumor burden, exert a robust antitumor immune response, and generate long-term immune protection to prevent tumor recurrence. This article is protected by copyright. All rights reserved.