LAUSR

Magnesium (Mg)‐based alloys have been regarded as promising implants for future clinic orthopedics, however, how to endow them with good anti‐corrosion and biofunctions still remains a great challenge, especially for complicated bone diseases. Herein, three transition metals (M = Mn, Fe, and Co)‐containing layered double hydroxides (LDH) (LDH‐Mn, LDH‐Fe, and LDH‐Co) with similar M content are prepared on Mg alloy via a novel two‐step method, then systematic characterizations and comparisons are conducted in detail. Results showed that LDH‐Mn exhibited the best corrosion resistance, LDH‐Mn and LDH‐Co possessed excellent photothermal and enzymatic activities, LDH‐Fe revealed better cytocompatibility and antibacterial properties, while LDH‐Co demonstrated high cytotoxicity. Based on these results, an optimized bilayer LDH coating enriched with Fe and Mn (LDH‐MnFe) from top to bottom have been designed for further in vitro and in vivo analysis. The top Fe‐riched layer provided biocompatibility and antibacterial properties, while the bottom Mn‐riced layer provided excellent anti‐corrosion, photothermal and enzymatic effects. In addition, the released Mg, Fe, and Mn ions have a positive influence on angiogenesis and osteogenesis. Thus, the LDH‐MnFe showed complementary and synergistic effects on anti‐corrosion and multibiofunctions (antibacteria, antitumor, and osteogenesis). The present work offers a novel multifunctional Mg‐based implant for treating bone diseases.