LAUSR

Insufficient angiogenesis frequently occurs after the implantation of orthopaedic materials, which greatly increases the risk of bone defect reconstruction failure. Therefore, the development of bone implant with improved angiogenic properties is of great importance. Mimicking the extracellular matrix clues provides a more direct and effective strategy to modulate angiogenesis. Herein, inspired by the bioelectrical characteristics of bone microenvironment, a piezoelectric bioactive glasses composite (P-KNN/BG) based on the incorporation of polarized potassium sodium niobate was constructed, which could effectively promote angiogenesis. We found that P-KNN/BG had exceptional wireless electrical stimulation performance and sustained active ions release. In vitro cell experiments revealed that P-KNN/BG enhanced endothelial cell adhesion, migration, and differentiation via activating the eNOS/NO signaling pathway, which might be contributed to cell membrane hyperpolarization induced by wireless electrical stimulation increased the influx of active ions into the cells. In vivo chick chorioallantoic membrane experiment demonstrated that P-KNN/BG showed excellent pro-angiogenic capacity and biocompatibility. This work broadens the current understanding of bioactive materials with bionic electrical properties, which brings new insights into the clinical treatment of bone defect repair. This article is protected by copyright. All rights reserved.