LAUSR

Combination of platinum(II) metallacycles and photodynamic inactivation presents a promising antibacterial strategy. Herein, we developed a cascaded artificial light-capturing system in which an aggregation-induced emission-active platinum(II) metallacycle (PtTPEM) was utilized as the antenna, sulforhodamine 101 (SR101) as a key conveyor, and the near-infrared emissive photosensitizer Chlorin-e6 (Ce6) as the final energy acceptor. The well-dispersed Ce6 in the proximity of energy donors not only avoided self-quenching in the physiological environment but also contributed to energy transfer from donor to acceptor, thereby significantly improving the 1 O2 generation ability of the light-harvesting system under white light irradiation. By integrating the platinum(II) metallacycle and 1 O2 , a more efficient synergistic antibacterial effect was achieved at low concentrations, along with a significant decrease in dark toxicity caused by PtTPEM. This article is protected by copyright. All rights reserved.