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CAR-T lymphocytes show modest therapeutic efficacy in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure (IFP), increases blood perfusion, releases antigens, and promotes… Click to show full abstract
CAR-T lymphocytes show modest therapeutic efficacy in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure (IFP), increases blood perfusion, releases antigens, and promotes the recruitment of endogenous immune cells. In article number 1900192, Gianpietro Dotti, Zhen Gu, and co-workers find that CSPG4-specific CAR-T cells infused in NSG mice engrafted with the human melanoma WM115 cell line had superior antitumor activity after photothermal ablation of the tumor. These findings suggest that photothermal therapy facilitates the accumulation and effector function of CAR-T cells within tumors.
Journal Title: Advanced Materials
Year Published: 2019
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