LAUSR

Fe-N-C single-atom catalysts (SACs) exhibit excellent peroxidase (POD)-like catalytic activity, owing to their well-defined isolated iron active sites on the carbon substrate, which effectively mimic the Fe-Nx active site's structure of natural peroxidase. To further meet the requirements of diverse biosensing applications, SACs POD-like activity still needs to be continuously enhanced. Herein, we introduce phosphorus heteroatoms to boost the POD-like activity of Fe-N-C SAC. A one-dimensional carbon nanowire (FeNCP/NW) catalyst with enriched Fe-N4 active sites is designed and synthesized, and phosphorus (P) atoms are doped in the carbon matrix to affect the Fe center through the long-range interaction. The experimental results show that the phosphorus-doping process can boost the POD-like activity more than the non-P-doped one with excellent selectivity and stability. The mechanism analysis results show that the introduction of P into SAC can first significantly enhance POD-like activity, and then decrease with increasing amount of P. As a proof of concept, the FeNCP/NW is employed in an enzyme cascade platform for highly-sensitive colorimetric detection of the neurotransmitter acetylcholine. This article is protected by copyright. All rights reserved.