LAUSR

This research reports synthesis of novel graft copolymers of oatmeal (OAT-g-PMMA) using a methyl methacrylate monomer via the “microwave-assisted” technique which were applied as matrices. The synthesized matrices were used to develop the bioavailability of model drug (5-amino salicylic acid (5-ASA)) for colon-targeted delivery. Characterization of novel synthesized matrices includes intrinsic viscosity, 13C-CP/MAS solid-state NMR spectroscopy, FTIR, DSC, SEM, TGA, UV, and elemental analysis. In vitro release studies of 5-ASA were performed in simulated gastric medium (pH 2) and simulated intestinal medium (pH 7 and 7.4). The release rate of 5-ASA from OAT-g-PMMA matrices was found to be slower than oatmeal in simulated gastric media. However, the reverse trend was observed in simulated intestinal medium. These results suggest that synthesized novel OAT-g-PMMA matrices are more suitable for oral delivery of applied model drug as compared to starting biopolymer (oatmeal) with special reference followed by the Fickian diffusion mechanism as a colonic drug carrier.