LAUSR

Studies related to selection of molar mass of hyaluronic acid and analysis of rheological properties of hyaluronic acid solutions modified with bioactive substances, used in spinning, were undertaken within the presented work. A cephalosporin group antibiotic, Biofuroxime®, was used, together with the nanoadditives zinc oxide (ZnO) and hydroxyapatite (HAp). Electrospinning studies were performed on selected solutions using a large scale laboratory station, allowing the process to be performed using three nozzles supplying the spinning solution. Optimum electrospinning conditions were selected on the basis of the performed study, which allow fibrous structures made of elementary fibres with diameters below 200 nm to be obtained. Studies showed that the most preferred distance between the nozzle and the collecting manifold was 450 mm and the most preferred applied voltage was 30 kV. The obtained, modified nanofibres of hyaluronic acid comprise structures for use in the production of biomaterials with a wide range of applications in tissue engineering.