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The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising… Click to show full abstract
The sustained release of drug at adequate and stable cytosolic drug concentrations is found to be a feasible scheme to circumvent the multidrug resistance effect and serves as a promising guideline for drug design to overcome drug resistance in cancer therapeutics. In article number https://doi.org/10.1002/advs.201700289, Quan Li and co‐workers demonstrate the feasibility of using self‐decomposable nanoparticle drug carriers as intracellular drug reservoirs that enable delivery of a stable therapeutic concentration, leading to complete reversal of multidrug resistance.
Journal Title: Advanced Science
Year Published: 2018
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