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In article number 1801521, Hyunjoon Kong and co‐workers demonstrate that substrate topography regulates neural innervation by enhancing maturity of the myotubes. Neural stem cells are differentiated on the myotubes, formed… Click to show full abstract
In article number 1801521, Hyunjoon Kong and co‐workers demonstrate that substrate topography regulates neural innervation by enhancing maturity of the myotubes. Neural stem cells are differentiated on the myotubes, formed on grooved substrates. The motor neurons innervate more actively to the mature myotubes formed on the 1600 nm groove width. Accordingly, those myotubes respond more rapidly to neurotransmitter and neuromuscular antagonists. The results of this study will be useful for improving the quality of engineered muscle used in applications such as drug screening, regeneration therapies, and biological machinery assembly.
Journal Title: Advanced Science
Year Published: 2019
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