LAUSR

Abstract Core–shell structured magnetic mesoporous polymer or carbon‐based microspheres not only possess the combined merits of magnetic particles and stable mesoporous shell but also provide various organic functional groups for further modification and immobilization of active sites, thus opening up more possibility for various applications. Herein, a bottom‐up soft‐templating strategy is developed to controllably synthesize core–shell magnetic mesoporous polydopamine microspheres (MMP) and their derivative magnetic mesoporous carbon (MMC) microspheres via an amphiphilic block copolymer‐directed interface assembly and polymerization (denoted as abc‐DIAP) approach. The obtained uniform MMP microspheres have a well‐defined structure consisting of magnetic core, silica middle layer and mesoporous PDA shell, uniform mesopores of 11.9 nm, high specific surface areas (235.6 m2 g−1) and rich functional groups. They show fast magnetic separation speed and superior performance in selective adsorption of Cyt.C from complex biosample solutions. Moreover, they can be in situ converted into core–shell magnetic mesoporous carbon (MMC) for efficient in‐pore immobilization of ultrafine Au nanoparticles for high‐efficiency catalytic epoxidation of styrene with high conversion (88.6%) and selectivity (90.1%) toward styrene oxide.