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of Hematology, Papa Giovanni XXIII hospital, Bergamo, Italy; Division of Hematology, Medical University of Vienna, Vienna, Austria; Division of Hematology, S. Bortolo Hospital, Vicenza, Italy; Department of Hematology, University of Padua, Padua, Italy; Institute of Pathology University of Cologne, Cologne, Germany; Division of Hematology Department of Medicine, Mayo Clinic, Rochester, Minnesota Additional Supporting Information may be found in the online version of this article. Conflict of Interest: None of the authors have any conflict of interest to disclose in regards to the current manuscript. T.B. designed the study, interpreted the data and wrote the paper. A.M.V., E.R., G.B., H.G., M.R., M.L.R., M.C., A.R., B.G., L.P. collected patient’s data of the main cohort. J.T. reviewed the bone marrow histopathology, A.C. performed data analysis, A.P. and A.T. critically revised the article. All authors discussed the results and implications and commented on the manuscript, giving the final approval of the version to be published. *Correspondence to: Tiziano Barbui, Fondazione per la Ricerca Ospedale Maggiore di Bergamo (FROM), Ospedale Papa Giovanni XXIII, Piazza OMS, 1 24127 Bergamo (BG), ITALY, Tel.: 139(0)35267 5134 – 4436. Fax: 139(0)35267 4926. E-mail: [email protected] Contract grant sponsors: Associazione Italiana per la Ricerca sul Cancro (AIRC, Milano) “Special Program Molecular Clinical Oncology 5 3 1000” to AGIMM (AIRC-Gruppo Italiano Malattie Mieloproliferative)Received for publication: 5 October 2016; Revised: 10 October 2016; Accepted: 11 October 2016 Published online: 13 October 2016 in Wiley Online Library (wileyonlinelibrary.com) DOI: 10.1002/ajh.24583