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Efficacy and safety of half‐dose desmopressin for bleeding prophylaxis in bleeding disorder patients undergoing predominantly low to moderate risk invasive procedures

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of disease in pyruvate kinase deficiency and their management. Haematologica. 2020:haematol.2019.240846. https://doi.org/10.3324/ haematol.2019.240846. 5. Necheles TF, Finkel HE, Sheehan RG, Allen DM. Red cell pyruvate kinase deficiency. The effect of… Click to show full abstract

of disease in pyruvate kinase deficiency and their management. Haematologica. 2020:haematol.2019.240846. https://doi.org/10.3324/ haematol.2019.240846. 5. Necheles TF, Finkel HE, Sheehan RG, Allen DM. Red cell pyruvate kinase deficiency. The effect of splenectomy. Arch Intern Med. 1966; 118(1):75-78. 6. Oski FA. Clinical consequences of enzyme deficiencies in the erythrocyte. Ann Clin Lab Sci. 1971;1(2):177-183. 7. Vichinsky E. Non-transfusion-dependent thalassemia and thalassemia intermedia: epidemiology, complications, and management. Curr Med Res Opin. 2016;32(1):191-204. 8. Al-Samkari H, Addonizio K, Glader B, et al. The pyruvate kinase (PK) to hexokinase enzyme activity ratio and erythrocyte PK protein level in the diagnosis and phenotype of PK deficiency. Br J Haematol. 2020. https://doi.org/10.1111/bjh.16724.

Keywords: pyruvate kinase; half dose; efficacy safety; desmopressin bleeding; safety half; dose desmopressin

Journal Title: American Journal of Hematology
Year Published: 2020

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