LAUSR

REFERENCES 1. Nader E, Conran N, Romana M, Connes P. Vasculopathy in sickle cell disease: from red blood cell sickling to vascular dysfunction. Compr Physiol. 2009;84(9):618-625. 2. Bernaudin F, Verlhac S, Chevret S, et al. G6PD deficiency, absence of alpha-thalassemia, and hemolytic rate at baseline are significant independent risk factors for abnormally high cerebral velocities in patients with sickle cell anemia. Blood. 2008;112(10):4314-4317. 3. Nolan VG, Adewoye A, Baldwin C, et al. Sickle cell leg ulcers: associations with haemolysis and SNPs in Klotho, TEK and genes of the TGFbeta/BMP pathway. Br J Haematol. 2006;133(5):570-578. 4. Alvarez RA, Miller MP, Hahn SA, et al. Targeting pulmonary endothelial hemoglobin alpha improves nitric oxide signaling and reverses pulmonary artery endothelial dysfunction.AmJRespir CellMol Biol. 2017;57(6):733-744. 5. Straub AC, Lohman AW, Billaud M, et al. Endothelial cell expression of haemoglobin alpha regulates nitric oxide signalling. Nature. 2012; 491(7424):473-477. 6. Straub AC, Butcher JT, Billaud M, et al. Hemoglobin alpha/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction. Arterioscler Thromb Vasc Biol. 2014;34(12):2594-2600. 7. Charlot K, Romana M, Moeckesch B, et al. Which side of the balance determines the frequency of vaso-occlusive crises in children with sickle cell anemia: blood viscosity or microvascular dysfunction? Blood Cells Mol Dis. 2016;56(1):41-45. 8. Denton CC, Shah P, Suriany S, et al. Loss of alpha-globin genes in human subjects is associated with improved nitric oxide-mediated vascular perfusion. Am J Hematol. 2020;96(3):277-281. 9. Higashi Y, Sasaki S, Nakagawa K, et al. Low body mass index is a risk factor for impaired endothelium-dependent vasodilation in humans: role of nitric oxide and oxidative stress. J Am Coll Cardiol. 2003;42(2):256-263. 10. Etyang AO, Khayeka-Wandabwa C, Kapesa S, et al. Blood pressure and arterial stiffness in Kenyan adolescents with alpha(+)thalassemia. J Am Heart Assoc. 2017;6(4):e005613. Received: 8 January 2021 Revised: 9 February 2021 Accepted: 9 February 2021