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A 21-year-old man was under follow-up after a second hematopoietic stem cell transplant with umbilical cord blood (UCBT) for relapsed acute myeloid leukemia. One month after UCBT, he was in… Click to show full abstract
A 21-year-old man was under follow-up after a second hematopoietic stem cell transplant with umbilical cord blood (UCBT) for relapsed acute myeloid leukemia. One month after UCBT, he was in complete remission with incomplete count recovery (CRi, hemoglo-bin concentration 85 g/L, platelets 13 (cid:1) 10 9 /L, and neutrophils 1.2 (cid:1) 10 9 /L). Donor chimerism was 100%. Eleven days later, a sudden increase in the lymphocyte count from 0.5 to 2.1 (cid:1) 10 9 /L was observed concomitantly with human herpesvirus 6 (HHV6) reactiva-tion with a peripheral blood viral load at log 3.32 copies/mL. Examina-tion of the blood film revealed 41% large atypical lymphocytes with a high nucleocytoplasmic ratio, irregular nucleus, decondensed chroma-tin with indistinct nucleoli, and weakly basophilic cytoplasm with irregular protrusions (images May-Grünwald-Giemsa, (cid:1) 100 objective). Flow cytometric immunophenotyping showed polyclonal CD19 + B cells
Journal Title: American Journal of Hematology
Year Published: 2022
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