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Regulation of inflammation during gestation and birth outcomes: Inflammatory cytokine balance predicts birth weight and length

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The maternal environment during gestation influences offspring health at birth and throughout the life course. Recent research has demonstrated that endogenous immune processes such as dysregulated inflammation adversely impact birth… Click to show full abstract

The maternal environment during gestation influences offspring health at birth and throughout the life course. Recent research has demonstrated that endogenous immune processes such as dysregulated inflammation adversely impact birth outcomes, increasing the risk for preterm birth and restricted fetal growth. Prior analyses examining this association suggest a relationship between maternal C‐reactive protein (CRP), a summary measure of inflammation, and offspring anthropometric outcomes. This study investigates pro‐ and anti‐inflammatory cytokines, and their ratio, to gain deeper insight into the regulation of inflammation during pregnancy.

Keywords: gestation; birth; inflammation; regulation inflammation; birth outcomes

Journal Title: American Journal of Human Biology
Year Published: 2019

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