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The palladium-catalyzed three-component coupling of (chloromethyl)arenes or (chloromethyl)heteroarenes, allytrimethoxysilane, and carbon dioxide (carboxylative Hiyama coupling reaction) was successfully conducted to produce α,β-unsaturated esters in satisfactory to good yields. The carboxylative… Click to show full abstract
The palladium-catalyzed three-component coupling of (chloromethyl)arenes or (chloromethyl)heteroarenes, allytrimethoxysilane, and carbon dioxide (carboxylative Hiyama coupling reaction) was successfully conducted to produce α,β-unsaturated esters in satisfactory to good yields. The carboxylative Hiyama coupling reaction proceeded smoothly under mild conditions in the presence of palladium nanoparticles through the formation of π-allylpalladium chloride intermediates.
Journal Title: Asian Journal of Organic Chemistry
Year Published: 2017
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