LAUSR

The catalytic synthesis of organic sulfenamides and disulfides has great significance and value in synthetic chemistry and bioscience. To establish a versatile and efficient technology for such reactions, we successfully developed a new aerobic oxidative coupling method to construct S-N/S-S bonds, which uses TEMPO as the catalyst, and O2 as the oxidant. A variety of amines and thiols were well tolerated. Sulfenamides were produced in up to 99% yield while disulfides were formed in up to 97% yield in one-pot synthesis. The activation of N-H bond by 2,2-disbenzothiazoledisulfide showed the great potential in organic synthesis.