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Ipso-Nitration of 2-Halothiophenes with Silver Nitrate

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It is described a simple method for the ipso-nitration of aryl substituted 2-halothiophenes, which produce 2-nitrothiophenes with regioselectivity is described. The method involves AgNO3 as the nitration reagent without further… Click to show full abstract

It is described a simple method for the ipso-nitration of aryl substituted 2-halothiophenes, which produce 2-nitrothiophenes with regioselectivity is described. The method involves AgNO3 as the nitration reagent without further additives to conduct the transformation.

Keywords: nitration; chemistry; nitration halothiophenes; silver nitrate; ipso nitration; halothiophenes silver

Journal Title: Asian Journal of Organic Chemistry
Year Published: 2017

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