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Efficient N‐Nitrosation of Sulfonamides with tert‐Butyl Nitrite at Room Temperature

Sulfonamide is one of the most important structures in organic chemistry due to its presence in natural products and pharmaceuticals. Herein, we disclose a simple, highly efficient, and direct one‐step… Click to show full abstract

Sulfonamide is one of the most important structures in organic chemistry due to its presence in natural products and pharmaceuticals. Herein, we disclose a simple, highly efficient, and direct one‐step synthesis of N‐nitroso sulfonamides in excellent yields within 30 minutes employing sulfonamides and tert‐butyl nitrite at room temperature in open air. This method could be used effectively to produce a variety of value‐added N‐nitroso sulfonamides.

Keywords: chemistry; sulfonamides tert; nitrite room; butyl nitrite; room temperature; tert butyl

Journal Title: Asian Journal of Organic Chemistry
Year Published: 2025

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