A synthetic method that relies on base‐promoted allylation(propargylation)/propargyl‐allenyl isomerization/dehydro‐Diels−Alder cascade of 1,3‐enynyl alcohols for the synthesis of structurally diverse phthalan derivatives under metal‐free mild reaction conditions is described. Moreover, the… Click to show full abstract
A synthetic method that relies on base‐promoted allylation(propargylation)/propargyl‐allenyl isomerization/dehydro‐Diels−Alder cascade of 1,3‐enynyl alcohols for the synthesis of structurally diverse phthalan derivatives under metal‐free mild reaction conditions is described. Moreover, the protocol could be further expanded to the synthesis of 3,5‐disubstituted‐5,7‐dihydrofuro[3,4‐b]pyridines simply by changing the allyl or propargyl bromides to 2‐bromoacetonitrile.
Journal Title: Asian Journal of Organic Chemistry
Year Published: 2025
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