A copper(I)‐catalyzed four‐component interrupted click/amination cascade reaction for the efficient synthesis of various 5‐amino‐1,2,3‐triazoles has been developed. The key step in this reaction is the interception of the in situ‐formed… Click to show full abstract
A copper(I)‐catalyzed four‐component interrupted click/amination cascade reaction for the efficient synthesis of various 5‐amino‐1,2,3‐triazoles has been developed. The key step in this reaction is the interception of the in situ‐formed cuprate‐triazole intermediate with O ‐benzoylhydroxylamine. This four‐component reaction proceeds under mild conditions with complete regioselectivity. It's also characterized by a broad substrate scope and good functional group tolerance.
Keywords:
catalyzed four;
component;
component interrupted;
copper catalyzed;
four component;
interrupted click
Journal Title: Asian Journal of Organic Chemistry
Year Published: 2025
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Journal Title: Asian Journal of Organic Chemistry
Year Published: 2025
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!