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Sporadic inclusion body myositis (sIBM), an intractable progressive muscle disease, frequently occurs in older persons. sIBM pathogenesis may involve protein degradation dysfunction and immune abnormalities. Autoantibodies recognizing cytosolic 5′‐nucleotidase 1A… Click to show full abstract
Sporadic inclusion body myositis (sIBM), an intractable progressive muscle disease, frequently occurs in older persons. sIBM pathogenesis may involve protein degradation dysfunction and immune abnormalities. Autoantibodies recognizing cytosolic 5′‐nucleotidase 1A (cN1A) were found in plasma and serum from sIBM patients. However, whether anti‐cN1A autoantibodies play a pathogenic role in sIBM is controversial. This study investigated the pathogenic properties of anti‐cN1A autoantibodies in sIBM pathogenesis.
Journal Title: Annals of Neurology
Year Published: 2017
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