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Sustainable method for Alzheimer dementia prediction in mild cognitive impairment: Electroencephalographic connectivity and graph theory combined with apolipoprotein E

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Mild cognitive impairment (MCI) is a condition intermediate between physiological brain aging and dementia. Amnesic‐MCI (aMCI) subjects progress to dementia (typically to Alzheimer‐Dementia = AD) at an annual rate which is 20… Click to show full abstract

Mild cognitive impairment (MCI) is a condition intermediate between physiological brain aging and dementia. Amnesic‐MCI (aMCI) subjects progress to dementia (typically to Alzheimer‐Dementia = AD) at an annual rate which is 20 times higher than that of cognitively intact elderly. The present study aims to investigate whether EEG network Small World properties (SW) combined with Apo‐E genotyping, could reliably discriminate aMCI subjects who will convert to AD after approximately a year.

Keywords: sustainable method; dementia; alzheimer dementia; cognitive impairment; mild cognitive

Journal Title: Annals of Neurology
Year Published: 2018

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