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Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

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Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with inflammatory demyelinating diseases of the central nervous system (CNS). We analyzed their pathogenic activity by affinity‐purifying these… Click to show full abstract

Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with inflammatory demyelinating diseases of the central nervous system (CNS). We analyzed their pathogenic activity by affinity‐purifying these antibodies (Abs) from patients and transferring them to experimental animals.

Keywords: myelin oligodendrocyte; antibodies myelin; pathogenicity human; human antibodies; oligodendrocyte glycoprotein

Journal Title: Annals of Neurology
Year Published: 2018

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