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TMEM106B Effect on cognition in Parkinson disease and frontotemporal dementia

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Common variants near TMEM106B associate with risk of developing frontotemporal dementia (FTD). Emerging evidence suggests a role for TMEM106B in neurodegenerative processes beyond FTD. We evaluate the effect of TMEM106B… Click to show full abstract

Common variants near TMEM106B associate with risk of developing frontotemporal dementia (FTD). Emerging evidence suggests a role for TMEM106B in neurodegenerative processes beyond FTD. We evaluate the effect of TMEM106B genotype on cognitive decline across multiple neurogenerative diseases.

Keywords: frontotemporal dementia; effect cognition; tmem106b effect; dementia

Journal Title: Annals of Neurology
Year Published: 2019

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