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In our recently published study we found that at the onset of PML serum NfL were 10-fold higher than in the pre-PML condition and in natalizumab-treated or untreated MS patients.… Click to show full abstract
In our recently published study we found that at the onset of PML serum NfL were 10-fold higher than in the pre-PML condition and in natalizumab-treated or untreated MS patients. The findings by Loonstra et al., with four additional cases with an increase in serum NfL at PML onset, support our results and further explore the dynamics of these changes. In fact they showed that also in asymptomatic patients NfL were already increased, and that NfL levels mirror PML lesion volume. This suggests that NfL may represent an early and accessible marker of PML. This article is protected by copyright. All rights reserved.
Journal Title: Annals of Neurology
Year Published: 2019
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