"Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents"

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Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents

To analyze why numerous acute stroke treatments were successful in the laboratory but failed in large clinical trials. Click to show full abstract

To analyze why numerous acute stroke treatments were successful in the laboratory but failed in large clinical trials.

Keywords: phase; stroke studies; acute stroke; clinical trials; studies positive; positive animals

Journal Title: Annals of Neurology
Year Published: 2019

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