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Value of Onconeural Antibodies in Checkpoint Inhibitor‐Related Toxicities

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Value of Onconeural Antibodies in Checkpoint Inhibitor-Related Toxicities Alberto Vogrig, MD , Sergio Muñiz-Castrillo, MD , and Jérôme Honnorat, MD, PhD An increasing number of patients will be exposed to… Click to show full abstract

Value of Onconeural Antibodies in Checkpoint Inhibitor-Related Toxicities Alberto Vogrig, MD , Sergio Muñiz-Castrillo, MD , and Jérôme Honnorat, MD, PhD An increasing number of patients will be exposed to immune checkpoint inhibitors (ICIs) in the forthcoming future; therefore, it is crucial for neurologists to acquire experience in managing neurological immune-related adverse events (n-irAEs) associated with their use. Dubey et al recently described in Annals of Neurology 28 patients with n-irAEs. Surprisingly, they stated that in both the literature and in their series the neurological presentations rarely mimicked those of classical paraneoplastic neurological syndromes (PNSs). Moreover, they suspected that “these

Keywords: related toxicities; onconeural antibodies; antibodies checkpoint; value onconeural; checkpoint inhibitor; inhibitor related

Journal Title: Annals of Neurology
Year Published: 2020

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