LAUSR

chain (sNfL) observed by Chung et al in their cohort with bacterial pneumonia. Important in our view is the observation that neuronal damage occurs in the course of both COVID-19 and sepsisassociated encephalopathy (ie, also in absence of overt infection of the central nervous system). We agree that neuronal damage is not specific for COVID-19, but seems likely a generic consequence in severe infectious disease of various etiologies. We agree as well that the role of renal dysfunction and other metabolic changes as factors modulating NfL levels during infectious diseases needs to be explored.