LAUSR

core volume and mismatch ratio in the MT group (Figure 3 from Reference 1), showing that increasing core volume significantly mitigates the relationship between mismatch ratio and clinical effects of MT versus BMM. Regarding safety, the aim of our study was not to determine the factors associated with parenchymal hemorrhage (PH) after MT, but whether the persistence of significant penumbra modifies the effects of MT in comparison to BMM on PH. Our findings show a higher risk of PH in the MT group, regardless of the mismatch ratio. In other words, the major benefits derived from penumbral salvage following MT in patients with significant mismatch clearly outweighed any negative impact of PH on functional outcome. Conversely, the lack of beneficial effect of MT on outcome together with the higher odds of PH points to MT being not only “not beneficial,” but also potentially harmful in patients without mismatch. Finally, it was not possible to “factor in the model” the imaging-to-puncture delay, as per definition the BMM group had no groin puncture. However, the imaging-to-puncture delay in the MT group did not differ according to the occurrence of PH: 51 minutes (interquartile range [IQR] = 44–74) versus 63 minutes (IQR = 45–78) in patients with versus without PH, respectively (p = 0.88).