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T he most common cause of dementia in older adults is Alzheimer disease (AD), a speci fi c neurodegenerative disease that is de fi ned by the presence of amyloid… Click to show full abstract
T he most common cause of dementia in older adults is Alzheimer disease (AD), a speci fi c neurodegenerative disease that is de fi ned by the presence of amyloid plaques and tau tangles in the brain. Although, for many years, an autopsy was required to de fi nitively diagnose AD, this has changed with the development of AD biomarkers that re fl ect AD brain pathology. Amyloid and tau positron emission tomography (PET), and cerebrospinal fl uid (CSF) levels of amyloid- β 42 (A β 42), total tau, and tau phosphorylated at position 181, are highly correlated with AD brain pathology. These biomarkers are now widely used in research and clinical trials. Appropriate use criteria for amyloid PET and CSF 4
Journal Title: Annals of Neurology
Year Published: 2022
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