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Human endogenous retroviruses have been implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous retrovirus K (HERV‐K) subtype HML‐2 envelope (Env) in human neuronal cultures and… Click to show full abstract
Human endogenous retroviruses have been implicated in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous retrovirus K (HERV‐K) subtype HML‐2 envelope (Env) in human neuronal cultures and in transgenic mice results in neurotoxicity and neurodegeneration, and mice expressing HML‐2 Env display behavioral and neuromuscular characteristics resembling ALS. This study aims to characterize the neurotoxic properties of HML‐2 Env.
Keywords:
lateral sclerosis;
endogenous retrovirus;
human endogenous;
amyotrophic lateral
Journal Title: Annals of Neurology
Year Published: 2022
Link to full text (if available)
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Journal Title: Annals of Neurology
Year Published: 2022
Link to full text (if available)
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recommendations!