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Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury

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Previous studies have established the role of the cortico‐mesolimbic and descending pain modulation systems in chronic pain prediction. Mild traumatic brain injury (mTBI) is an acute pain model where chronic… Click to show full abstract

Previous studies have established the role of the cortico‐mesolimbic and descending pain modulation systems in chronic pain prediction. Mild traumatic brain injury (mTBI) is an acute pain model where chronic pain is prevalent and complicated for prediction. In this study, we set out to study whether functional connectivity (FC) of the nucleus accumbens (NAc) and the periaqueductal gray matter (PAG) is predictive of pain chronification in early‐acute mTBI.

Keywords: traumatic brain; brain; mild traumatic; chronic pain; pain; brain injury

Journal Title: Annals of Neurology
Year Published: 2022

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