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Central Role of Macrophages and Nucleic Acid Release in Myasthenia Gravis Thymus

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Myasthenia gravis (MG) is a neuromuscular disease mediated by antibodies against the acetylcholine receptor (AChR). The thymus plays a primary role in AChR‐MG and is characterized by a type I… Click to show full abstract

Myasthenia gravis (MG) is a neuromuscular disease mediated by antibodies against the acetylcholine receptor (AChR). The thymus plays a primary role in AChR‐MG and is characterized by a type I interferon (IFN) signature linked to IFN‐β. We investigated if AChR‐MG was characterized by an IFN‐I signature in the blood, and further investigated the chronic thymic IFN‐I signature.

Keywords: ifn signature; myasthenia gravis; central role; myasthenia

Journal Title: Annals of Neurology
Year Published: 2022

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