could be triggered by molecular mimicry or bystander activation of pre-existing MOG-specific memory B cells, which can be detected in patients with MOGAD, but occasionally in healthy donors, and can… Click to show full abstract
could be triggered by molecular mimicry or bystander activation of pre-existing MOG-specific memory B cells, which can be detected in patients with MOGAD, but occasionally in healthy donors, and can differentiate into MOG-IgG producing plasmablasts by toll-like receptor engagement. Induction of MOG-IgG after different vaccines as well as transient appearance of MOG-IgG (anti-vaccine antibodies are longer lasting) would be compatible with a bystander activation of autoreactive B cells. MOG-IgG are pathogenic, but they require an opening of the blood–brain barrier to enter the CNS, which may be caused by inflammatory cytokines produced after infection or vaccination.
Journal Title: Annals of Neurology
Year Published: 2023
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