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A facile and efficient synthesis of 3‐cyanoindoles by a simple palladium(II)‐catalyzed C─H activation of indoles

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An efficient trans-PdCl2(NH2CH2COOH)2-catalyzed direct C3-cyanation of indole C─H bonds is described. Notably, free (N─H)-indoles reacted smoothly using the procedure, and the desired product 3-cyanoindoles were obtained in good to excellent… Click to show full abstract

An efficient trans-PdCl2(NH2CH2COOH)2-catalyzed direct C3-cyanation of indole C─H bonds is described. Notably, free (N─H)-indoles reacted smoothly using the procedure, and the desired product 3-cyanoindoles were obtained in good to excellent yields.

Keywords: simple palladium; efficient synthesis; facile efficient; palladium catalyzed; cyanoindoles simple; synthesis cyanoindoles

Journal Title: Applied Organometallic Chemistry
Year Published: 2017

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