LAUSR

Two novel polymeric complexes were synthesized from the reaction of AgClO4 with 3‐amino‐6‐(chloromethyl)‐2‐pyrazinecarbonitrile 4‐oxide (L1‐Cl) or 3‐aminopyrazine‐2‐carboxylic acid (HL2) to give [Ag(L1‐OCH3)(μ‐OClO3)]n; (1) or [Ag (HL2)(OClO3)]n.nH2O; (2), respectively. 3‐Amino‐6‐(methoxymethyl)‐2‐pyrazinecarbonitrile 4‐oxide (L1‐OCH3) is formed by the etherification process that occurred during the synthesis of complex 1. The complexes architectures were investigated by single‐crystal XRD (SC‐XRD). Both complexes have novel and different polymeric forms based on the pyrazine moiety that adopt a bridging mode between the Ag(I) sites with the difference of donor atoms in each complex. The silver(I) centers in the polymeric chain of complex 1 are connected to one another through the bridging pyrazine ligand and perchlorate anions in an alternative manner. In complex 2, HL2 does not only act as a linker between the silver centers but also as a bidentate ligand. Hirshfeld surface analysis demonstrated the importance of H···O contacts in the supramolecular structures of 1 (41.7%) and 2 (30.2%). Biological investigations indicated promising antimicrobial and anticancer properties of these water‐soluble complexes. Particularly, complex 1 displays interesting activity against A‐549 (IC50 = 10.53 ± 0.44 𝜇M) and MCF‐7 (IC50 = 8.41 ± 0.31 𝜇M) cell lines when contrasted to cis‐platin. Regarding antibacterial action, the most promising MIC value and inhibition zone diameter are 8 μg/mL and 20 mm, respectively, for 1 against B. subtilis.