LAUSR

RosA is a phenolic acid compound extracted from perilla. In this experiment, the Oxford cup method was used to verify the antibacterial activity of Perilla rosmarinic acid (RosA) against Escherichia coli, Staphylococcus aureus, Salmonella and Bacillus subtilis. By polyacrylamide gel electrophoresis (SDS-PAGE), the effect of RosA on bacterial nucleic acid and bacterial Na+/K+-ATP-ase activity, and scanning electron microscope (SEM) to exploration of its antibacterial mechanism preliminarily. The results showed that RosA had antibacterial properties against all four bacteria. The MIC and MBC of E. coli was 0.8 mg/mL and 0.9 mg/mL, respectively. The MIC and MBC of Salmonella was 0.9 mg/mL and 1.0 mg/mL, respectively. The MIC and MBC of S. aureus and B. subtilis was both 1.0 mg/mL and 1.1 mg/mL. RosA has the bacteriostasis function, which can destroy bacterial cells and cell proteins and inhibit the activity of Na+ /K+ -ATP-ase in cells. This article is protected by copyright. All rights reserved.