The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation… Click to show full abstract
The aim of study was to generate quantitative data on the abundance of drug‐metabolizing enzymes and transporters (DMETs) in inflamed and non‐inflamed Crohn's disease (CD) ileum and colon, for incorporation into physiologically based pharmacokinetic (PBPK) models, enabling prediction of oral drugs' pharmacokinetics (PK) perturbation in CD patients.
Keywords:
crohn disease;
enzymes transporters;
drug;
variability intestinal;
drug metabolizing;
metabolizing enzymes
Journal Title: British Journal of Clinical Pharmacology
Year Published: 2025
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Journal Title: British Journal of Clinical Pharmacology
Year Published: 2025
Link to full text (if available)
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recommendations!