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Medication adherence during the run‐in phase of clinical trials: A systematic review of methodological and reporting rigour

Trial run‐in phases are sometimes used to select adherent participants as a strategy to enrich trials, but the methods employed lack clear regulatory guidance and there are concerns about the… Click to show full abstract

Trial run‐in phases are sometimes used to select adherent participants as a strategy to enrich trials, but the methods employed lack clear regulatory guidance and there are concerns about the transparency of reporting. This review aims to characterize the methods used for adherence measurement and public reporting of run‐in studies.

Keywords: reporting; review; medication adherence; adherence; run phase; adherence run

Journal Title: British Journal of Clinical Pharmacology
Year Published: 2025

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