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Cannabidiol impairs neural tube closure in mouse whole embryo culture

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Cannabidiol (CBD) is a nonpsychoactive constituent of cannabis widely available as a dietary supplement. Previous reports that it impairs the retinoid, sonic hedgehog, and folate metabolism pathways raise concern that… Click to show full abstract

Cannabidiol (CBD) is a nonpsychoactive constituent of cannabis widely available as a dietary supplement. Previous reports that it impairs the retinoid, sonic hedgehog, and folate metabolism pathways raise concern that it may impair closure of the embryonic neural tube (NT), producing NT defects including spina bifida and exencephaly.

Keywords: impairs neural; cannabidiol; closure; cannabidiol impairs; neural tube

Journal Title: Birth Defects Research
Year Published: 2022

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